Cefixime

Cefixime

· The first and the only one third generation cephalosporin can administered by oral.

· Pediatric dose : 1,5 – 3 mg/kgbb given orally twice daily, may be increased until 6 mg/kgbb twice daily for severe infection.

· Adult dose : usually 100 mg given twice daily. In gonorhoea, given 400 mg as single dose.

· Active to so much gram positive ( Streptokokus sp ) and negative aerobic microorganism .( Haemopilus influenzae, Neisseria gonororrheae, E.coli )

· Very active against Enterobactericeae microorganism.

· It is extremely stable to beta lactamase produced by many organism.

· Less activity against gram positive coccus microorganism than first cephalosporin.

· There is no activity against Stafilokokus aureus and penisillin resisten pneumococcus.

· Used in uncomplicated urinary tract nfection, otitis media, pharyngitis, tonsillitis, acute bronchitis.

· Treatment of typhoid fever in children with multi drug resisten to standart regimen.

· Preucations in pregnant and nursing woman ( not contraindication ).

· Contraindication : allergy/hypersensitivity with any ingredient by this product.

· Cefixime is generally well tolerated and side effects are usually transient. Reported side effects include diarrhea, pseudomembranous colitis (can occur even after cefixime is stopped) nausea, abdominal pain, vomiting, skin rash, fever, joint pain and arthritis, abnormal liver tests, vaginitis, itching, headaches, and dizziness.